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Epidermal Growth Factor: Identification of a New Hormone in Human Urine

Ralph H. Starkey, Stanley Cohen and David N. Orth
Science
New Series, Vol. 189, No. 4205 (Sep. 5, 1975), pp. 800-802
Stable URL: http://www.jstor.org/stable/1740213
Page Count: 3
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Epidermal Growth Factor: Identification of a New Hormone in Human Urine
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Abstract

Epidermal growth factor is a polypeptide hormone that was previously identified only in mice. It causes proliferation and keratinization of epidermal tissues. An immune affinity column extraction technique was used to purify partially a substance from human urine which was similar to the mouse hormone in both its biological activity and immunoreactivity.

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