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Transmission of Creutzfeldt-Jakob Disease from Man to the Guinea Pig

Elias E. Manuelidis
Science
New Series, Vol. 190, No. 4214 (Nov. 7, 1975), pp. 571-572
Stable URL: http://www.jstor.org/stable/1740443
Page Count: 2
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Abstract

Intracerebral and intraperitoneal inoculation of two guinea pigs with biopsy material from a patient with Creutzfeldt-Jakob disease produced a similar fatal encephalopathy characterized by status spongiosus 422 and 512 days after inoculation. Serial transmission of this disease from guinea pig to guinea pig was achieved in subsequent passages.

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