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Diphenylhydantoin: Action of a Common Anticonvulsant on Bursting Pacemaker Cells in Aplysia

Daniel Johnston and Giovanni F. Ayala
Science
New Series, Vol. 189, No. 4207 (Sep. 19, 1975), pp. 1009-1011
Stable URL: http://www.jstor.org/stable/1740660
Page Count: 3
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Diphenylhydantoin: Action of a Common Anticonvulsant on Bursting Pacemaker Cells in Aplysia
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Abstract

A commonly used anticonvulsant, diphenylhydantoin (Dilantin), decreases the bursting pacemaker activity in certain cells of Aplysia. Dilantin decreases this bursting activity whether it is endogenous to the cell or induced by a convulsant agent. The sodium-dependent negative resistance characteristic which is essential for bursting behavior is reduced in the presence of Dilantin.

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