Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Retention of Nonhelical Procollagen Containing cis-Hydroxyproline in Rough Endoplasmic Reticulum

Jouni Uitto, Hans-Peter Hoffmann and Darwin J. Prockop
Science
New Series, Vol. 190, No. 4220 (Dec. 19, 1975), pp. 1202-1204
Stable URL: http://www.jstor.org/stable/1742071
Page Count: 3
  • More info
  • Cite this Item
Preview not available
Preview not available

Abstract

Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen. Evidence is presented here that the nonhelical procollagen containing the analog is retained within the rough endoplasmic reticulum and does not pass to the smooth endoplasmic reticulum or Golgi vacuoles at a normal rate.

Page Thumbnails

  • Thumbnail: Page 
1202
    1202
  • Thumbnail: Page 
1203
    1203
  • Thumbnail: Page 
1204
    1204