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Journal Article

Derepressed Alloantigen on Transplacentally Induced Lung Tumor Coded for by H-2 Linked Gene

W. J. Martin, T. G. Gipson, S. E. Martin and J. M. Rice
Science
New Series, Vol. 194, No. 4264 (Oct. 29, 1976), pp. 532-533
Stable URL: http://www.jstor.org/stable/1742479
Page Count: 2

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Topics: Tumors, Lungs, Spleen cells, Isoantigens, Cell growth, Immunity, Haplotypes, Genetic loci, Hybridity, Antiserum
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Abstract

A transplacentally induced lung tumor of strain C3Hf mice grows progressively when transplanted to (C3Hf × A)F$_{1}$ hybrid mice but not when transplanted to C3Hf recipients. Progressive tumor growth occurs in [(C3Hf × A)F$_{1}\times $ C3Hf] backcross mice inheriting the H-2$^{a}$ haplotype from the F$_{1}$ parent. Furthermore, radioresistant immunity to the lung tumor can be induced in C3Hf mice by immunization with normal tissue of B10.A and B10.A(2R) but not of B10 or B10.A(5R) strain mice.

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