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Journal Article

Surgical Removal of Adipose Tissue Alters Feeding Behavior and the Development of Obesity in Rats

Irving M. Faust, Patricia R. Johnson and Jules Hirsch
Science
New Series, Vol. 197, No. 4301 (Jul. 22, 1977), pp. 393-396
Stable URL: http://www.jstor.org/stable/1744355
Page Count: 4

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Topics: Adipocytes, Rats, Fats, Lipids, Adipose tissues, High fat diet, Food intake, Obesity, Body fat, Body weight
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Surgical Removal of Adipose Tissue Alters Feeding Behavior and the Development of Obesity in Rats
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Abstract

Lipectomized and sham-operated rats were fed a high-fat diet to induce hyperphagia and rapid fat accumulation. Lipectomized rats with 25 percent fewer adipocytes were less hyperphagic and accumulated less fat, but their adipocytes remained equal in size to adipocytes of controls. A role for adipocyte size in fat storage regulation and food intake control is postulated.

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