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Fasting Decreases Triiodothyronine Receptor Capacity

George C. Schussler and Joseph Orlando
Science
New Series, Vol. 199, No. 4329 (Feb. 10, 1978), pp. 686-688
Stable URL: http://www.jstor.org/stable/1745590
Page Count: 3
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Fasting Decreases Triiodothyronine Receptor Capacity
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Abstract

Fasting decreases the ratio of hepatic nuclear to serum triiodothyronine (T$_{3}$) by diminishing the binding capacity of nuclear T$_{3}$ receptors. In combination with the lower serum T$_{3}$ concentration caused by fasting, the decrease in receptor content results in a marked decrease in nuclear T$_{3}$-receptor complexes. The changes in T$_{3}$ receptor content and circulating T$_{3}$ in fasted animals appear to be independent synergistic adaptations for caloric conservation in the fasted state. Unlike changes in hormonal level, the modification of nuclear receptor content provides a mechanism that may protect cells with a low caloric reserve independently of the metabolic status of the whole animal.

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