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Journal Article

Manufactured Hexaparental Mice Show That Adults Are Derived from Three Embryonic Cells

Clement L. Markert and Robert M. Petters
Science
New Series, Vol. 202, No. 4363 (Oct. 6, 1978), pp. 56-58
Stable URL: http://www.jstor.org/stable/1746110
Page Count: 3

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Topics: Embryos, Chimeras, Germ cells, Mice, Embryonic cells, Albinism, Genotypes, Blastocyst, Chimerism, Pigments
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Manufactured Hexaparental Mice Show That Adults Are Derived from Three Embryonic Cells
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Abstract

Two female chimeric mice have been produced by aggregates of three genetically marked eight-cell embryos. All three embryonic genotypes are clearly expressed in the pigment pattern of the adults. These hexaparental mice together with their littermates demonstrate that, in the 64-celled blastocyst, at least three cells, and probably only three, are the source of all adult tissues.

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