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Trisodium Phosphonoformate, a New Antiviral Compound
E. Helgstrand, B. Eriksson, N. G. Johansson, B. Lannerö, A. Larsson, A. Misiorny, J. O. Norén, B. Sjöberg, K. Stenberg, G. Stening, S. Stridh, B. Öberg, S. Alenius and L. Philipson
New Series, Vol. 201, No. 4358 (Sep. 1, 1978), pp. 819-821
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1746142
Page Count: 3
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Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorabies virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.
Science © 1978 American Association for the Advancement of Science