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Cystic Fibrosis: Decreased Conjugation and Excretion of [$^{14}$C]Spermidine

Michael G. Rosenblum, Brian G. M. Durie, Robert C. Beckerman, Lynn M. Taussig and Diane Haddock Russell
Science
New Series, Vol. 200, No. 4349 (Jun. 30, 1978), pp. 1496-1497
Stable URL: http://www.jstor.org/stable/1746671
Page Count: 2
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Abstract

Free and conjugated [$^{14}$C]spermidine were measured in plasma samples from normal individuals and cystic fibrosis patients. Within 4 minutes, the $^{14}$C-labeled material in the plasma from normal individuals was 70 percent conjugated compared to no detectable conjugation by cystic fibrosis patients. Further, the patients excreted only 11 to 13 percent of the [$^{14}$C]spermidine in their urine within 72 hours whereas normal excretion was 60 to 76 percent. In both cases, the labeled material was in a conjugated form.

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