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A Regulatory Locus for Mouse β-Glucuronidase Induction, Gur, Controls Messenger RNA Activity
Kenneth Paigen, Cesar Labarca and Gordon Watson
New Series, Vol. 203, No. 4380 (Feb. 9, 1979), pp. 554-556
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1747180
Page Count: 3
You can always find the topics here!Topics: Messenger RNA, RNA, Kidneys, Oocytes, Enzymes, Genetic loci, Alleles, Gene induction, Genetics, Mice
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A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney β-glucuronidase messenger RNA activity after induction of the β-glucuronidase structural gene, Gus, by testosterone. β-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine β-glucuronidase in Xenopus oocytes.
Science © 1979 American Association for the Advancement of Science