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A Regulatory Locus for Mouse β-Glucuronidase Induction, Gur, Controls Messenger RNA Activity

Kenneth Paigen, Cesar Labarca and Gordon Watson
Science
New Series, Vol. 203, No. 4380 (Feb. 9, 1979), pp. 554-556
Stable URL: http://www.jstor.org/stable/1747180
Page Count: 3
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A Regulatory Locus for Mouse β-Glucuronidase Induction, Gur, Controls Messenger RNA Activity
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Abstract

A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney β-glucuronidase messenger RNA activity after induction of the β-glucuronidase structural gene, Gus, by testosterone. β-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine β-glucuronidase in Xenopus oocytes.

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