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Regional Localization of the Gene for Human Phosphoribosylpyrophosphate Synthetase on the X Chromosome
Michael A. Becker, Richard C. K. Yen, Pamela Itkin, Stephen J. Goss, J. Edwin Seegmiller and Bohdan Bakay
New Series, Vol. 203, No. 4384 (Mar. 9, 1979), pp. 1016-1019
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1747483
Page Count: 4
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Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase activity. The cells were grown under selective conditions requiring retention of the X chromosome-linked locus for human hypoxanthine-guanine phosphoribosyltransferase. The frequency and patterns of cotransference of human phosphoribosylpyrophosphate synthetase with the selected marker and with additional X-linked enzymatic markers confirm X linkage of the structural gene for human phosphoribosylpyrophosphate synthetase and support assignment of this gene to a position on the long arm of the X, between the loci for α-galactosidase and hypoxanthine-guanine phosphoribosyltransferase.
Science © 1979 American Association for the Advancement of Science