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Regional Localization of the Gene for Human Phosphoribosylpyrophosphate Synthetase on the X Chromosome

Michael A. Becker, Richard C. K. Yen, Pamela Itkin, Stephen J. Goss, J. Edwin Seegmiller and Bohdan Bakay
Science
New Series, Vol. 203, No. 4384 (Mar. 9, 1979), pp. 1016-1019
Stable URL: http://www.jstor.org/stable/1747483
Page Count: 4
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Regional Localization of the Gene for Human Phosphoribosylpyrophosphate Synthetase on the X Chromosome
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Abstract

Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase activity. The cells were grown under selective conditions requiring retention of the X chromosome-linked locus for human hypoxanthine-guanine phosphoribosyltransferase. The frequency and patterns of cotransference of human phosphoribosylpyrophosphate synthetase with the selected marker and with additional X-linked enzymatic markers confirm X linkage of the structural gene for human phosphoribosylpyrophosphate synthetase and support assignment of this gene to a position on the long arm of the X, between the loci for α-galactosidase and hypoxanthine-guanine phosphoribosyltransferase.

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