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Thyroxine Increases Nerve Growth Factor Concentration in Adult Mouse Brain
Peter Walker, Morton E. Weichsel, Jr., David A. Fisher, Shirley M. Guo and Delbert A. Fisher
New Series, Vol. 204, No. 4391 (Apr. 27, 1979), pp. 427-429
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1748398
Page Count: 3
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The effects of thyroxine and propylthiouracil on nerve growth factor concentrations in cerebral cortex, cerebellum, and brainstem of adult male mice were assessed by using a sensitive radioimmunoassay for the β-subunit of mouse nerve growth factor. Thyroxine administration significantly increased the concentration of nerve growth factor in all three brain areas compared to control values, whereas propylthiouracil was without effect. These results suggest that thyroid hormones stimulate nerve growth factor synthesis in the mature central nervous system, and raise the possibility that the influence of thyroid hormones on central nervous system development might be mediated or influenced by nerve growth factor.
Science © 1979 American Association for the Advancement of Science