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Thyroxine Increases Nerve Growth Factor Concentration in Adult Mouse Brain

Peter Walker, Morton E. Weichsel, Jr., David A. Fisher, Shirley M. Guo and Delbert A. Fisher
Science
New Series, Vol. 204, No. 4391 (Apr. 27, 1979), pp. 427-429
Stable URL: http://www.jstor.org/stable/1748398
Page Count: 3
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Thyroxine Increases Nerve Growth Factor Concentration in Adult Mouse Brain
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Abstract

The effects of thyroxine and propylthiouracil on nerve growth factor concentrations in cerebral cortex, cerebellum, and brainstem of adult male mice were assessed by using a sensitive radioimmunoassay for the β-subunit of mouse nerve growth factor. Thyroxine administration significantly increased the concentration of nerve growth factor in all three brain areas compared to control values, whereas propylthiouracil was without effect. These results suggest that thyroid hormones stimulate nerve growth factor synthesis in the mature central nervous system, and raise the possibility that the influence of thyroid hormones on central nervous system development might be mediated or influenced by nerve growth factor.

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