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Thyrotropin-Releasing Hormone Selectively Depresses Glutamate Excitation of Cerebral Cortical Neurons

L. P. Renaud, H. W. Blume, Q. J. Pittman, Y. Lamour and A. T. Tan
Science
New Series, Vol. 205, No. 4412 (Sep. 21, 1979), pp. 1275-1277
Stable URL: http://www.jstor.org/stable/1748567
Page Count: 3
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Thyrotropin-Releasing Hormone Selectively Depresses Glutamate Excitation of Cerebral Cortical Neurons
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Abstract

The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.

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