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Müllerian Duct Regression in the Embryo Correlated with Cytotoxic Activity Against Human Ovarian Cancer

Patricia K. Donahoe, David A. Swann, Akira Hayashi and Marcia D. Sullivan
Science
New Series, Vol. 205, No. 4409 (Aug. 31, 1979), pp. 913-915
Stable URL: http://www.jstor.org/stable/1748687
Page Count: 3
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Müllerian Duct Regression in the Embryo Correlated with Cytotoxic Activity Against Human Ovarian Cancer
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Abstract

A significant cytotoxicity index was obtained when human ovarian cancer cells in a microcytotoxicity assay were exposed during the S (DNA-synthesizing) phase of the cell cycle to purified fractions of testis exhibiting high Müllerian inhibiting substance bioactivity. The same effect was not observed when these fractions were tested against human glioblastoma or fibroblast lines. Most human ovarian cancers are said to resemble Müllerian tissues histologically. Müllerian inhibiting substance may thus deserve further study as a potential chemotherapeutic agent.

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