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Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes
Arthur A. Like, Aldo A. Rossini, Dennis L. Guberski, Michael C. Appel and R. Michael Williams
New Series, Vol. 206, No. 4425 (Dec. 21, 1979), pp. 1421-1423
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1749019
Page Count: 3
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Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morphologic and physiologic characteristics of human insulin-dependent diabetes mellitus.
Science © 1979 American Association for the Advancement of Science