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Journal Article

Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes

Arthur A. Like, Aldo A. Rossini, Dennis L. Guberski, Michael C. Appel and R. Michael Williams
Science
New Series, Vol. 206, No. 4425 (Dec. 21, 1979), pp. 1421-1423
Stable URL: http://www.jstor.org/stable/1749019
Page Count: 3
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Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes
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Abstract

Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morphologic and physiologic characteristics of human insulin-dependent diabetes mellitus.

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