Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes

Arthur A. Like, Aldo A. Rossini, Dennis L. Guberski, Michael C. Appel and R. Michael Williams
Science
New Series, Vol. 206, No. 4425 (Dec. 21, 1979), pp. 1421-1423
Stable URL: http://www.jstor.org/stable/1749019
Page Count: 3
  • More info
  • Cite this Item
Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes
Preview not available

Abstract

Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morphologic and physiologic characteristics of human insulin-dependent diabetes mellitus.

Page Thumbnails

  • Thumbnail: Page 
1421
    1421
  • Thumbnail: Page 
1422
    1422
  • Thumbnail: Page 
1423
    1423