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Target Cells for 1,25-Dihydroxyvitamin D$_{3}$ in Intestinal Tract, Stomach, Kidney, Skin, Pituitary, and Parathyroid

Walter E. Stumpf, Madhabananda Sar, Frederic A. Reid, Yoko Tanaka and Hector F. DeLuca
Science
New Series, Vol. 206, No. 4423 (Dec. 7, 1979), pp. 1188-1190
Stable URL: http://www.jstor.org/stable/1749170
Page Count: 3
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Target Cells for 1,25-Dihydroxyvitamin D$_{3}$ in Intestinal Tract, Stomach, Kidney, Skin, Pituitary, and Parathyroid
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Abstract

After mature rats that had been fed on a vitamin D$_{3}$-deficient diet were injected with tritium-labeled 1,25-dihydroxyvitamin D$_{3}$, radioactivity became concentrated in nuclei of luminal and cryptal epithelium of the duodenum, jejunum, ileum, and colon; in nuclei of the epithelium of kidney distal tubules including the macula densa, and in podocytes of glomeruli; in nuclei of the epidermis including outer hairshafts and sebaceous glands; and in nuclei of certain cells of the stomach, anterior and posterior pituitary, and parathyroid. These results reveal cell types that contain receptors for 1,25-dihydroxyvitamin D$_{3}$ or metabolites of this compound both in known or hypothesized target tissues and in tissues that were previously unknown to participate in vitamin D$_{3}$ metabolism.

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