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The Maternal Nucleolus Is Essential for Early Embryonic Development in Mammals

Sugako Ogushi, Chiara Palmieri, Helena Fulka, Mitinori Saitou, Takashi Miyano and Josef Fulka Jr.
Science
New Series, Vol. 319, No. 5863 (Feb. 1, 2008), pp. 613-616
Stable URL: http://www.jstor.org/stable/20053256
Page Count: 4
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Abstract

With fertilization, the paternal and maternal contributions to the zygote are not equal. The oocyte and spermatozoon are equipped with complementary arsenals of cellular structures and molecules necessary for the creation of a developmentally competent embryo. We show that the nucleolus is exclusively of maternal origin. The maternal nucleolus is not necessary for oocyte maturation; however, it is necessary for the formation of pronuclear nucleoli after fertilization or parthenogenetic activation and is essential for further embryonic development. In addition, the nucleolus in the embryo produced by somatic cell nuclear transfer originates from the oocyte, demonstrating that the maternal nucleolus supports successful embryonic development.

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