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Endometrial Adenocarcinoma in a Bengal Tiger (Panthera tigris bengalensis) Implanted with Melengestrol Acetate

Richard M. Linnehan, Jeffrey L. Edwards and Jeffery L. Edwards
Journal of Zoo and Wildlife Medicine
Vol. 22, No. 1 (Mar., 1991), pp. 130-134
Stable URL: http://www.jstor.org/stable/20095130
Page Count: 5
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Endometrial Adenocarcinoma in a Bengal Tiger (Panthera tigris bengalensis) Implanted with Melengestrol Acetate
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Abstract

A 13-yr-old female bengal tiger (Panthera tigris bengalensis) had been implanted subcutaneously three times at 2-yr intervals with melengestrol acetate, a progestin compound used as a contraceptive in exotic felids. The tiger subsequently developed a moderately well-differentiated endometrial adenocarcinoma with direct extension to the broad ligament, left ovary, left kidney, and sublumbar lymph nodes. This is the second incidence of this tumor type in a bengal tiger implanted with melengestrol, suggesting a possible link between the exogenous progestin and uterine cancer in exotic felids.

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