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Pharmacokinetics of Piperacillin in Blood Pythons (Python curtus) and in vitro Evaluation of Efficacy against Aerobic Gram-Negative Bacteria

Megan Hilf, Douglas Swanson, Robert Wagner and Victor L. Yu
Journal of Zoo and Wildlife Medicine
Vol. 22, No. 2 (Jun., 1991), pp. 199-203
Stable URL: http://www.jstor.org/stable/20095142
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Pharmacokinetics of Piperacillin in Blood Pythons (Python curtus) and in vitro Evaluation of Efficacy against Aerobic Gram-Negative Bacteria
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Abstract

A pharmacokinetic and microbiological evaluation of the potential use of piperacillin, an extended spectrum beta-lactam, in blood pythons (Python curtus) was conducted. Minimum inhibitory concentrations (MIC) of piperacillin and gentamicin were determined for species of gramnegative bacilli isolated from the upper respiratory tract of snakes diagnosed with penumonia. Minimum inhibitory concentrations ranged from 0.25 to 4.0 mcg/ml for piperacillin and from 0.125 to >32 mcg/ml for gentamicin. Five blood pythons were given a 200 mg/kg loading dose of piperacillin followed by 100 mg/kg at 24 and 48 hr. Pharmacokinetic indices were determined following the third dose of 100 mg/kg. Peak serum concentrations ranged from 142.6 to 274 mcg/ml and occurred 4 hr after the last dose. Serum half-life was 12.3-17 hr, and total clearance was 0.89-3.21 ml/min. We recommend a piperacillin dose of 100 mg/kg at 48-hr intervals for this species. This dose provides serum concentrations well in excess of the MIC of piperacillin for aerobic gramnegative bacilli isolated from the upper respiratory tract of snakes with pneumonia. There was no observed effect on renal function, as measured by increased uric acid concentrations, associated with this dosage regimen.

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