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Safety of Milbemycin (A₃-A₄ Oxime) in Chelonians

Michael S. Bodri, Thomas J. Nolan and Sandra J. Skeeba
Journal of Zoo and Wildlife Medicine
Vol. 24, No. 2 (Jun., 1993), pp. 171-174
Stable URL: http://www.jstor.org/stable/20095259
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Safety of Milbemycin (A₃-A₄ Oxime) in Chelonians
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Abstract

Red-eared sliders (Pseudemys scripta elegans) were given ivermectin (0.2 mg/kg), milbemycin (A₃-A₄ oxime) (0.5 or 1.0 mg/kg), or propylene glycol (0.2 ml/kg) p.o. to determine the sensitivity of these animals to these drugs and from these data to infer the safety of milbemycin. Half of the ivermectin-treated turtles showed paresis or flaccid paralysis. One animal died, and histology of the liver indicated a diffuse fatty change. No clinical evidence of toxicity was noted in the milbemycin-treated animals. A group of red-eared sliders and six Gulf Coast box turtles (Terrapene carolina major) were given 0.5 mg/kg milbemycin s.c. in the front leg. No deleterious effects or site reactions were clinically detected. Five ornate box turtles (Terrapene carolina ornata) with patent helminth infestations were treated s.c. with 0.25 mg/kg milbemycin and ceased to shed eggs in their feces following 1 or 2 doses.

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