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Safety of Milbemycin (A₃-A₄ Oxime) in Chelonians
Michael S. Bodri, Thomas J. Nolan and Sandra J. Skeeba
Journal of Zoo and Wildlife Medicine
Vol. 24, No. 2 (Jun., 1993), pp. 171-174
Published by: American Association of Zoo Veterinarians
Stable URL: http://www.jstor.org/stable/20095259
Page Count: 4
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Red-eared sliders (Pseudemys scripta elegans) were given ivermectin (0.2 mg/kg), milbemycin (A₃-A₄ oxime) (0.5 or 1.0 mg/kg), or propylene glycol (0.2 ml/kg) p.o. to determine the sensitivity of these animals to these drugs and from these data to infer the safety of milbemycin. Half of the ivermectin-treated turtles showed paresis or flaccid paralysis. One animal died, and histology of the liver indicated a diffuse fatty change. No clinical evidence of toxicity was noted in the milbemycin-treated animals. A group of red-eared sliders and six Gulf Coast box turtles (Terrapene carolina major) were given 0.5 mg/kg milbemycin s.c. in the front leg. No deleterious effects or site reactions were clinically detected. Five ornate box turtles (Terrapene carolina ornata) with patent helminth infestations were treated s.c. with 0.25 mg/kg milbemycin and ceased to shed eggs in their feces following 1 or 2 doses.
Journal of Zoo and Wildlife Medicine © 1993 American Association of Zoo Veterinarians