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Programming DNA Tube Circumferences

Peng Yin, Rizal F. Hariadi, Sudheer Sahu, Harry M. T. Choi, Sung Ha Park, Thomas H. LaBean and John H. Reif
Science
New Series, Vol. 321, No. 5890 (Aug. 8, 2008), pp. 824-826
Stable URL: http://www.jstor.org/stable/20144557
Page Count: 3
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Abstract

Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.

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