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Reversal Of Folate Malabsorption In Tropical And Non-Tropical Sprue By Calf Jejunum

H. Baker, O. Frank, H. Ziffer, S. Feingold and A. A. Cintron-Rivera
The British Medical Journal
Vol. 3, No. 5616 (Aug. 24, 1968), pp. 472-474
Published by: BMJ
Stable URL: http://www.jstor.org/stable/20393789
Page Count: 3
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Reversal Of Folate Malabsorption In Tropical And Non-Tropical Sprue By Calf Jejunum
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Abstract

In eight patients with folic acid malabsorption the malabsorption was reversed only when a combination of either 250 mg. of lyophilized human jejunal juice or 5 g. of lyophilized calf jejunum with 5 mg. of synthetic folic acid was fed; calf liver was ineffective. The factors in calf jejunum that re-established folic acid absorption were heat-stable and did not form polyglutamyl folates on previous incubation with folic acid.

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