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Nephrotic Syndrome With Heart Disease: A Reappraisal

P. J. Hilton, N. F. Jones and J. R. Tighe
The British Medical Journal
Vol. 3, No. 5618 (Sep. 7, 1968), pp. 584-586
Published by: BMJ
Stable URL: http://www.jstor.org/stable/20393936
Page Count: 4
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Nephrotic Syndrome With Heart Disease: A Reappraisal
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Abstract

The evidence that heart failure alone may cause a nephrotic syndrome is inconclusive. Mercurial diuretics, which have also been implicated as a cause of the nephrotic syndrome, had been given in 23 of the 24 well-documented cases. Two cases of heart disease and nephrotic syndrome are described. Glomerular lesions were minimal on light microscopy, but thickening of the glomerular tuft basement membrane and partial fusion of the epithelial cell foot processes were apparent on elecronmicroscopy. The response to prednisone was such as to justify a trial of corticosteroid therapy in such cases despite the presence of cardiac disease.

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