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Evaluation Of A Serological Test For Tuberculosis

D. A. Mitchison, V. R. Aber, F. J. Ahmad, B. W. Allen and S. Devi
The British Medical Journal
Vol. 1, No. 6073 (May 28, 1977), pp. 1383-1384
Published by: BMJ
Stable URL: http://www.jstor.org/stable/20414599
Page Count: 2
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Abstract

The agglutination test of Nicholls was found to be ineffective in diagnosing active tuberculosis. A positive result (titre of 1/125 or more) was found in the serum of 74 (70%) out of 105 patients with newly diagnosed, smear-positive pulmonary tuberculosis; 61 (62%) out of 98 healthy family contacts; and 19 (63%) out of 30 patients with non-tuberculous conditions. These findings were not due to faulty technique since the results obtained at Hammersmith were similar to those obtained by Nicholls's laboratory in the same serum samples. Twenty-seven of the tuberculous patients who had a negative result before treatment were retested two months after the start of chemotherapy but showed no evidence of a rising titre.

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