Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Spinophilin Participates in Information Transfer at Immunological Synapses

Ona Bloom, Julia J. Unternaehrer, Aimin Jiang, Jeong-Sook Shin, Lélia Delamarre, Patrick Allen and Ira Mellman
The Journal of Cell Biology
Vol. 181, No. 2 (Apr. 21, 2008), pp. 203-211
Stable URL: http://www.jstor.org/stable/20475902
Page Count: 9
  • More info
  • Cite this Item
Spinophilin Participates in Information Transfer at Immunological Synapses
Preview not available

Abstract

The adaptive immune response is initiated by the presentation of peptides bound to major histocompatibility complex molecules on dendritic cells (DCs) to antigen-specific T lymphocytes at a junction termed the immunological synapse. Although much attention has been paid to cytoplasmic events on the T cell side of the synapse, little is known concerning events on the DC side. We have sought signal transduction components of the neuronal synapse that were also expressed by DCs. One such protein is spinophilin, a scaffolding protein of neuronal dendritic spines that regulates synaptic transmission. In inactive, immature DCs, spinophilin is located throughout the cytoplasm but redistributes to the plasma membrane upon stimulus-induced maturation. In DCs interacting with T cells, spinophilin is polarized dynamically to contact sites in an antigen-dependent manner. It is also required for optimal T cell activation because DCs derived from mice lacking spinophilin exhibit defects in antigen presentation both in vitro and in vivo. Thus, spinophilin may play analogous roles in information transfer at both neuronal and immunological synapses.

Page Thumbnails

  • Thumbnail: Page 
203
    203
  • Thumbnail: Page 
204
    204
  • Thumbnail: Page 
205
    205
  • Thumbnail: Page 
206
    206
  • Thumbnail: Page 
207
    207
  • Thumbnail: Page 
208
    208
  • Thumbnail: Page 
209
    209
  • Thumbnail: Page 
210
    210
  • Thumbnail: Page 
211
    211