Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Disease-Specific Gene Repositioning in Breast Cancer

Karen J. Meaburn, Prabhakar R. Gudla, Sameena Khan, Stephen J. Lockett and Tom Misteli
The Journal of Cell Biology
Vol. 187, No. 6 (Dec. 14, 2009), pp. 801-812
Stable URL: http://www.jstor.org/stable/20618385
Page Count: 12
  • More info
  • Cite this Item
Disease-Specific Gene Repositioning in Breast Cancer
Preview not available

Abstract

Genomes are nonrandomly organized within the three-dimensional space of the cell nucleus. Here, we have identified several genes whose nuclear positions are altered in human invasive breast cancer compared with normal breast tissue. The changes in positioning are gene specific and are not a reflection of genomic instability within the cancer tissue. Repositioning events are specific to cancer and do not generally occur in noncancerous breast disease. Moreover, we show that the spatial positions of genes are highly consistent between individuals. Our data indicate that cancer cells have disease-specific gene distributions. These interphase gene positioning patterns may be used to identify cancer tissues.

Page Thumbnails

  • Thumbnail: Page 
801
    801
  • Thumbnail: Page 
802
    802
  • Thumbnail: Page 
803
    803
  • Thumbnail: Page 
804
    804
  • Thumbnail: Page 
805
    805
  • Thumbnail: Page 
806
    806
  • Thumbnail: Page 
807
    807
  • Thumbnail: Page 
808
    808
  • Thumbnail: Page 
809
    809
  • Thumbnail: Page 
810
    810
  • Thumbnail: Page 
811
    811
  • Thumbnail: Page 
812
    812