Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Non-classical actions of testosterone and spermatogenesis

William H. Walker
Philosophical Transactions: Biological Sciences
Vol. 365, No. 1546, The biology and regulation of spermatogenesis (27 May 2010), pp. 1557-1569
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/20789160
Page Count: 13
  • Read Online (Free)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Non-classical actions of testosterone and spermatogenesis
Preview not available

Abstract

Testosterone is essential to maintain spermatogenesis and male fertility. In the absence of testosterone stimulation, spermatogenesis does not proceed beyond the meiosis stage. After withdrawal of testosterone, germ cells that have progressed beyond meiosis detach from supporting Sertoli cells and die, whereas mature sperm cannot be released from Sertoli cells resulting in infertility. The classical mechanism of testosterone action in which testosterone activates gene transcription by causing the androgen receptor to translocate to and bind specific DNA regulatory elements does not appear to fully explain testosterone regulation of spermatogenesis. This review discusses two non-classical testosterone signalling pathways in Sertoli cells and their potential effects on spermatogenesis. Specifically, testosterone-mediated activation of phospholipase C and calcium influx into Sertoli cells is described. Also, testosterone activation of Src, EGF receptor and ERK kinases as well as the activation of the CREB transcription factor and CREB-mediated transcription is reviewed. Regulation of germ cell adhesion to Sertoli cells and release of mature sperm from Sertoli cells by kinases regulated by the non-classical testosterone pathway is discussed. The evidence accumulated suggests that classical and non-classical testosterone signalling contribute to the maintenance of spermatogenesis and male fertility.

Page Thumbnails

  • Thumbnail: Page 
1557
    1557
  • Thumbnail: Page 
1558
    1558
  • Thumbnail: Page 
1559
    1559
  • Thumbnail: Page 
1560
    1560
  • Thumbnail: Page 
1561
    1561
  • Thumbnail: Page 
1562
    1562
  • Thumbnail: Page 
1563
    1563
  • Thumbnail: Page 
1564
    1564
  • Thumbnail: Page 
1565
    1565
  • Thumbnail: Page 
1566
    1566
  • Thumbnail: Page 
1567
    1567
  • Thumbnail: Page 
1568
    1568
  • Thumbnail: Page 
1569
    1569