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Journal Article

Free Boundary Problems in Controlled Release Pharmaceuticals: II. Swelling- Controlled Release

Donald S. Cohen and Thomas Erneux
SIAM Journal on Applied Mathematics
Vol. 48, No. 6 (Dec., 1988), pp. 1466-1474
Stable URL: http://www.jstor.org/stable/2101760
Page Count: 9
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Free Boundary Problems in Controlled Release Pharmaceuticals: II. Swelling- Controlled Release
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Abstract

A problem in controlled release pharmaceutical systems is formulated and studied. The device modeled is a polymer matrix containing an initially immobilized drug. The release of the drug is achieved by countercurrent diffusion through a penetrant solvent with the release rate being determined by the rate of diffusion of the solvent in the polymer. The mathematical theory yields a free boundary problem which is studied in various asymptotic regimes.

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