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Mitochondrial DNA Heteroplasmy in Drosophila mauritiana
Michel Solignac, Monique Monnerot and Jean-Claude Mounolou
Proceedings of the National Academy of Sciences of the United States of America
Vol. 80, No. 22, [Part 1: Biological Sciences] (Nov. 15, 1983), pp. 6942-6946
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/22786
Page Count: 5
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Mitochondrial DNA extracted from an isofemale strain of Drosophila mauritiana (subgroup melanogaster) appeared to be heterogeneous in size. A short genome [S; 18,500 base pairs (bp)] and a longer one (L; 19,000 bp) coexist in the preparation. The additional 500 bp have been located within the A+T-rich region. Hpa I digest patterns suggest that the S genome may carry a duplication of a 500-bp sequence including an Hpa I site and that the L genome may carry a triplication of the same sequence. At the 30th generation of the isofemale strain, 60 female genotypes were examined individually. Half of the flies were pure either for the S or the L DNA. The remaining 50% exhibited various degrees of heteroplasmy for the two DNA types. Among metazoan animals, this D. mauritiana strain offers an exceptional situation with regard to the number of individuals heterogeneous for mtDNA and the relative stability of heteroplasmy through generations.
Proceedings of the National Academy of Sciences of the United States of America © 1983 National Academy of Sciences