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Usefulness of the Two-Compartment Open Model in Pharmacokinetics

Carl M. Metzler
Journal of the American Statistical Association
Vol. 66, No. 333 (Mar., 1971), pp. 49-53
DOI: 10.2307/2284845
Stable URL: http://www.jstor.org/stable/2284845
Page Count: 5
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Usefulness of the Two-Compartment Open Model in Pharmacokinetics
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Abstract

Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed. This discussion shows that, in spite of the extreme simplification and obvious weaknesses of this model, it has properties that make it a useful tool in drug research when properly used.

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