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Screening with Cost-Effective Quality Control: Potential Applications to HIV and Drug Testing
J. L. Gastwirth and Wesley O. Johnson
Journal of the American Statistical Association
Vol. 89, No. 427 (Sep., 1994), pp. 972-981
Stable URL: http://www.jstor.org/stable/2290923
Page Count: 10
You can always find the topics here!Topics: Screening tests, HIV, Quality assurance, Cost estimates, Preclinical drug evaluation, AIDS, Statistics, Antibodies, Drug testing, Estimate reliability
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This article investigates the applicability of group testing as a quality control procedure to monitor the sensitivity of screening tests used to check the blood supply for infective agents or to check employees for drug use. The problem is important, as the accuracy of screening tests in the field may deteriorate over time. In the blood screening application, our results demonstrate that group testing the screened negatives provides a procedure with high power to detect a decline of .02 in the sensitivity of the original test when the prevalence in the population is quite low (.0001). Moreover, the procedure is cost-effective in the sense that the expected cost per human immunodeficiency virus (HIV) infection avoided could be less than 1 million, in contrast to much higher economic valuations of life that are used in regulatory analyses. The statistical properties of estimates of the prevalence, as well as those for the sensitivity and specificity of the screening test using the extra information obtained from the quality control procedure, are also presented.
Journal of the American Statistical Association © 1994 American Statistical Association