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Different Exon-Intron Organization at the 5 Part of a Mouse Class I Gene is Used to Generate a Novel H-2Kd-Related mRNA

Jean-Louis Lalanne, Madeleine Cochet, Anne-Marie Kummer, Gabriel Gachelin and Philippe Kourilsky
Proceedings of the National Academy of Sciences of the United States of America
Vol. 80, No. 24, [Part 1: Biological Sciences] (Dec. 15, 1983), pp. 7561-7565
Stable URL: http://www.jstor.org/stable/22986
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Different Exon-Intron Organization at the 5′ Part of a Mouse Class I Gene is Used to Generate a Novel H-2Kd-Related mRNA
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Abstract

A cDNA library constructed from liver mRNA of DBA/2 (H-2d) mice has been screened with H-2-specific probes. The nucleotide sequence of one clone (pH-2d-24) indicates that it derives from an H-2 gene with an unexpected exon-intron organization. Nucleotide sequence comparisons suggest that two distinct mRNAs are produced from a single H-2Kd gene by a mechanism involving the use of alternative splicing sites in its 5′ region. pH-2d-24 carries an open reading frame encoding a thus-far-undescribed polypeptide product identical to an H-2Kd-molecule, except for the NH2-terminal half of the first domain.

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