You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Different Exon-Intron Organization at the 5′ Part of a Mouse Class I Gene is Used to Generate a Novel H-2Kd-Related mRNA
Jean-Louis Lalanne, Madeleine Cochet, Anne-Marie Kummer, Gabriel Gachelin and Philippe Kourilsky
Proceedings of the National Academy of Sciences of the United States of America
Vol. 80, No. 24, [Part 1: Biological Sciences] (Dec. 15, 1983), pp. 7561-7565
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/22986
Page Count: 5
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
A cDNA library constructed from liver mRNA of DBA/2 (H-2d) mice has been screened with H-2-specific probes. The nucleotide sequence of one clone (pH-2d-24) indicates that it derives from an H-2 gene with an unexpected exon-intron organization. Nucleotide sequence comparisons suggest that two distinct mRNAs are produced from a single H-2Kd gene by a mechanism involving the use of alternative splicing sites in its 5′ region. pH-2d-24 carries an open reading frame encoding a thus-far-undescribed polypeptide product identical to an H-2Kd-molecule, except for the NH2-terminal half of the first domain.
Proceedings of the National Academy of Sciences of the United States of America © 1983 National Academy of Sciences