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Harnessing the placebo effect: the need for translational research

Luana Colloca and Franklin G. Miller
Philosophical Transactions: Biological Sciences
Vol. 366, No. 1572, Placebo effects in medicine: mechanisms and clinical implications (27 June 2011), pp. 1922-1930
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/23035548
Page Count: 9
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Harnessing the placebo effect: the need for translational research
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Abstract

Laboratory research recently has greatly enhanced the understanding of placebo and nocebo effects by identifying specific neuromodulators and brain areas associated with them. However, little progress has been made in translating this knowledge into improved patient care. Here, we discuss the limitations in our knowledge about placebo (and nocebo) effects and the need for translational research with the aim of guiding physicians in maximizing placebo effects and minimizing nocebo effects in their routine clinical practice. We suggest some strategies for how, when and why interventions to promote beneficial placebo responses might be administered in the clinical setting.

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