Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

RETINOBLASTOMA RELATED1 Regulates Asymmetric Cell Divisions in Arabidopsis

Annika K. Weimer, Moritz K. Nowack, Daniel Bouyer, Xin'Ai Zhao, Hirofumi Harashima, Sadaf Naseer, Freya De Winter, Nico Dissmeyer, Niko Geldner and Arp Schnittger
The Plant Cell
Vol. 24, No. 10 (OCTOBER 2012), pp. 4083-4095
Stable URL: http://www.jstor.org/stable/23327041
Page Count: 13
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
RETINOBLASTOMA RELATED1 Regulates Asymmetric Cell Divisions in Arabidopsis
Preview not available

Abstract

Formative, also called asymmetric, cell divisions produce daughter cells with different identities. Like other divisions, formative divisions rely first of all on the cell cycle machinery with centrally acting cyclin-dependent kinases (CDKs) and their cyclin partners to control progression through the cell cycle. However, it is still largely obscure how developmental cues are translated at the cellular level to promote asymmetric divisions. Here, we show that formative divisions in the shoot and root of the flowering plant Arabidopsis thaliana are controlled by a common mechanism that relies on the activity level of the Cdk1 homolog CDKA;1, with medium levels being sufficient for symmetric divisions but high levels being required for formative divisions. We reveal that the function of CDKA;1 in asymmetric cell divisions operates through a transcriptional regulation system that is mediated by the Arabidopsis Retinoblastoma homolog RBR1. RBR1 regulates not only cell cycle genes, but also, independent of the cell cycle transcription factor E2F, genes required for formative divisions and cell fate acquisition, thus directly linking cell proliferation with differentiation. This mechanism allows the implementation of spatial information, in the form of high kinase activity, with intracellular gating of developmental decisions.

Page Thumbnails

  • Thumbnail: Page 
[4083]
    [4083]
  • Thumbnail: Page 
4084
    4084
  • Thumbnail: Page 
4085
    4085
  • Thumbnail: Page 
4086
    4086
  • Thumbnail: Page 
4087
    4087
  • Thumbnail: Page 
4088
    4088
  • Thumbnail: Page 
4089
    4089
  • Thumbnail: Page 
4090
    4090
  • Thumbnail: Page 
4091
    4091
  • Thumbnail: Page 
4092
    4092
  • Thumbnail: Page 
4093
    4093
  • Thumbnail: Page 
4094
    4094
  • Thumbnail: Page 
4095
    4095