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Forcing a Sequential Experiment to be Balanced
Vol. 58, No. 3 (Dec., 1971), pp. 403-417
Stable URL: http://www.jstor.org/stable/2334377
Page Count: 15
You can always find the topics here!Topics: Random allocation, Selection bias, Experiment design, Control groups, Eigenvalues, Experimentation, Spectral energy distribution, Significance level, Maximum value, Markov chains
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Subjects arrive sequentially at an experimental site and must be assigned immediately to treatment or control groups. In order to avoid biasing the results of the experiment it is customary to make the assignments by independent flips of a fair coin, but in small-sized experiments this may result in a severe imbalance between the numbers of treatments and controls. This paper discusses a new method of assigning the subjects which tends to balance the experiment, but at the same time is not over vulnerable to various common forms of experimental bias.
Biometrika © 1971 Biometrika Trust