Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Point and Interval Estimation Following a Sequential Clinical Trial

Susan Todd, John Whitehead and Karen M. Facey
Biometrika
Vol. 83, No. 2 (Jun., 1996), pp. 453-461
Published by: Oxford University Press on behalf of Biometrika Trust
Stable URL: http://www.jstor.org/stable/2337615
Page Count: 9
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Point and Interval Estimation Following a Sequential Clinical Trial
Preview not available

Abstract

The usual methodology employed in analysis after a sequential clinical trial is based on orderings of the possible samples resulting from the design. However, this approach lacks flexibility for use in wider applications. In this paper two estimation techniques not based on orderings are considered and modified to obtain improved accuracy. A bias-adjusted maximum likelihood estimate together with a new and general method for setting confidence limits are discussed. The realistic scenario of group sequential monitoring is assumed and methods for exact estimation are given. Accuracy of the methodology after a triangular test and an O'Brien & Fleming test are demonstrated through simulation.

Page Thumbnails

  • Thumbnail: Page 
[453]
    [453]
  • Thumbnail: Page 
454
    454
  • Thumbnail: Page 
455
    455
  • Thumbnail: Page 
456
    456
  • Thumbnail: Page 
457
    457
  • Thumbnail: Page 
458
    458
  • Thumbnail: Page 
459
    459
  • Thumbnail: Page 
460
    460
  • Thumbnail: Page 
461
    461