You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Point and Interval Estimation Following a Sequential Clinical Trial
Susan Todd, John Whitehead and Karen M. Facey
Vol. 83, No. 2 (Jun., 1996), pp. 453-461
Stable URL: http://www.jstor.org/stable/2337615
Page Count: 9
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
The usual methodology employed in analysis after a sequential clinical trial is based on orderings of the possible samples resulting from the design. However, this approach lacks flexibility for use in wider applications. In this paper two estimation techniques not based on orderings are considered and modified to obtain improved accuracy. A bias-adjusted maximum likelihood estimate together with a new and general method for setting confidence limits are discussed. The realistic scenario of group sequential monitoring is assumed and methods for exact estimation are given. Accuracy of the methodology after a triangular test and an O'Brien & Fleming test are demonstrated through simulation.
Biometrika © 1996 Biometrika Trust