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Human Macrophage Scavenger Receptors: Primary Structure, Expression, and Localization in Atherosclerotic Lesions
Akiyo Matsumoto, Markoto Naito, Hiroshige Itakura, Shinji Ikemoto, Hitoshi Asaoka, Ikuho Hayakawa, Hiroshi Kanamori, Hiroyuki Aburtani, Fumimaro Takaku, Hiroshi Suzuki, Yukage Kobari, Tatsuya Miyai, Kiyoshi Takahashi, Edward H. Cohen, Robert Wydro, David E. Housman and Tatsuhiko Kodama
Proceedings of the National Academy of Sciences of the United States of America
Vol. 87, No. 23 (Dec., 1990), pp. 9133-9137
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2355775
Page Count: 5
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Two types of cDNAs for human macrophage scavenger receptors were cloned from a cDNA library derived from the phorbol ester-treated human monocytic cell line THP-1. The type I and type II human scavenger receptors encoded by these cDNAs are homologous (73% and 71% amino acid identity) to their previously characterized bovine counterparts and consist of six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), α-helical coiled-coil (IV), collagen-like (V), and a type-specific C-terminal (VI). The receptor gene is located on human chromosome 8. The human receptors expressed in CHO-K1 cells mediated endocytosis of modified low density lipoproteins. Two mRNAs, 4.0 and 3.2 kilobases, have been detected in human liver, placenta, and brain. Immunohistochemical studies using an anti-peptide antibody which recognizes human scavenger receptors indicated the presence of the scavenger receptors in the macrophages of lipid-rich atherosclerotic lesions, suggesting the involvement of scavenger receptors in atherogenesis.
Proceedings of the National Academy of Sciences of the United States of America © 1990 National Academy of Sciences