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Identification of the Ancestral Haplotype for Apolipoprotein B Suggests an African Origin of Homo sapiens sapiens and Traces Their Subsequent Migration to Europe and the Pacific

Jan Rapacz, Linda Chen, Esther Butler-Brunner, Ming-Jiuan Wu, Judith O. Hasler-Rapacz, Rene Butler and Verne N. Schumaker
Proceedings of the National Academy of Sciences of the United States of America
Vol. 88, No. 4 (Feb. 15, 1991), pp. 1403-1406
Stable URL: http://www.jstor.org/stable/2356003
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Identification of the Ancestral Haplotype for Apolipoprotein B Suggests an African Origin of Homo sapiens sapiens and Traces Their Subsequent Migration to Europe and the Pacific
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Abstract

The probable ancestral haplotype for human apolipoprotein B (apoB) has been identified through immunological analysis of chimpanzee and gorilla serum and sequence analysis of their DNA. Moreover, the frequency of this ancestral apoB haplotype among different human populations provides strong support for the African origin of Homo sapiens sapiens and their subsequent migration from Africa to Europe and to the Pacific. The approach used here for the identification of the ancestral human apoB haplotype is likely to be applicable to many other genes.

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