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Calciseptine, a Peptide Isolated From Black Mamba Venom, is a Specific Blocker of the L-Type Calcium Channel

Jan R. de Weille, Hugues Schweitz, Pierrette Maes, Andre Tartar and Michel Lazdunski
Proceedings of the National Academy of Sciences of the United States of America
Vol. 88, No. 6 (Mar. 15, 1991), pp. 2437-2440
Stable URL: http://www.jstor.org/stable/2356398
Page Count: 4
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Calciseptine, a Peptide Isolated From Black Mamba Venom, is a Specific Blocker of the L-Type Calcium Channel
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Abstract

The venom of the black mamba contains a 60-amino acid peptide called calciseptine. The peptide has been fully sequenced. It is a smooth muscle relaxant and an inhibitor of cardiac contractions. Its physiological action resembles that of drugs, such as the 1,4-dihydropyridines, which are important in the treatment of cardiovascular diseases. Calciseptine, like the 1,4-dihydropyridines, selectively blocks L-type Ca2+ channels and is totally inactive on other voltage-dependent Ca2+ channels such as N-type and T-type channels. To our knowledge, it is the only natural polypeptide that has been shown to be a specific inhibitor of L-type Ca2+ channels.

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