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Inhibition of the Activation of Hageman Factor (Factor XII) by Human Vascular Endothelial Cell Culture Supernates

Oscar D. Ratnoff, Barbara Everson, Paula Embury, Nicholas P. Ziats, James M. Anderson, Marlene M. Emanuelson and Charles J. Malemud
Proceedings of the National Academy of Sciences of the United States of America
Vol. 88, No. 23 (Dec. 1, 1991), pp. 10740-10743
Stable URL: http://www.jstor.org/stable/2358327
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Inhibition of the Activation of Hageman Factor (Factor XII) by Human Vascular Endothelial Cell Culture Supernates
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Abstract

The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.

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