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Inhibition of the Activation of Hageman Factor (Factor XII) by Human Vascular Endothelial Cell Culture Supernates
Oscar D. Ratnoff, Barbara Everson, Paula Embury, Nicholas P. Ziats, James M. Anderson, Marlene M. Emanuelson and Charles J. Malemud
Proceedings of the National Academy of Sciences of the United States of America
Vol. 88, No. 23 (Dec. 1, 1991), pp. 10740-10743
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2358327
Page Count: 4
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The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.
Proceedings of the National Academy of Sciences of the United States of America © 1991 National Academy of Sciences