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Basolateral Amygdala Lesions Block Diazepam-Induced Anterograde Amnesia in an Inhibitory Avoidance Task
Carlos Tomaz, Heather Dickinson-Anson and James L. McGaugh
Proceedings of the National Academy of Sciences of the United States of America
Vol. 89, No. 8 (Apr. 15, 1992), pp. 3615-3619
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2359151
Page Count: 5
You can always find the topics here!Topics: Lesions, Amygdala, Benzodiazepines, Behavioral neuroscience, Memory, Amnesia, Antianxiety agents, Rats, Vehicles, Neurobiology
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This experiment examined the effects of diazepam (DZP) on acquisition and retention of an inhibitory avoidance response by rats with excitotoxic-induced lesions of central (CE), lateral (LAT), or basolateral (BL) amygdala nuclei. Sham-operated and lesioned rats received i.p. injections of DZP (2.0 mg per kg of body weight) 30 min before training in a continuous multiple-trial inhibitory avoidance task. Retention was tested 48 h later. Acquisition was not impaired by the lesions or the DZP. Retention was impaired in animals with CE and LAT lesions in comparison with sham-operated controls. DZP impaired retention in the sham-operated controls as well as CE- and LAT-lesioned animals but did not affect retention in animals with BL lesions. These findings indicate that the DZP-induced anterograde amnesia for inhibitory avoidance training is mediated through influences involving the BL amygdala nucleus.
Proceedings of the National Academy of Sciences of the United States of America © 1992 National Academy of Sciences