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A Membrane-Based Force Generation Mechanism in Auditory Sensory Cells
Federico Kalinec, Matthew C. Holley, Kuni H. Iwasa, David J. Lim and Bechara Kachar
Proceedings of the National Academy of Sciences of the United States of America
Vol. 89, No. 18 (Sep. 15, 1992), pp. 8671-8675
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2360247
Page Count: 5
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Auditory outer hair cells can elongate and shorten at acoustic frequencies in response to changes of plasma membrane potential. We show that this fast bidirectional contractile activity consists of an electromechanical transduction process that occurs at the lateral plasma membrane and can be activated and analyzed independently in small membrane patches inside a patch electrode. Bidirectional forces are generated by increases and decreases in membrane area in response to hyperpolarization and depolarization, respectively. We suggest that the force generation mechanism is driven by voltage-dependent conformational changes within a dense array of large transmembrane proteins associated with the site of electromechanical transduction.
Proceedings of the National Academy of Sciences of the United States of America © 1992 National Academy of Sciences