Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Evidence for a Chimeric Nature of Nuclear Genomes: Eubacterial Origin of Eukaryotic Glyceraldehyde-3-Phosphate Dehydrogenase Genes

William Martin, Henner Brinkmann, Catherine Savonna and Rudiger Cerff
Proceedings of the National Academy of Sciences of the United States of America
Vol. 90, No. 18 (Sep. 15, 1993), pp. 8692-8696
Stable URL: http://www.jstor.org/stable/2362917
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Evidence for a Chimeric Nature of Nuclear Genomes: Eubacterial Origin of Eukaryotic Glyceraldehyde-3-Phosphate Dehydrogenase Genes
Preview not available

Abstract

Higher plants possess two distinct, nuclear gene-encoded glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins, a Calvin-cycle enzyme active within chloroplasts and a glycolytic enzyme active within the cytosol. The gene for the chloroplast enzyme was previously suggested to be of endosymbiotic origin. Since the ancestors of plastids were related to cyanobacteria, we have studied GAPDH genes in the cyanobacterium Anabaena variabilis. Our results confirm that the nuclear gene for higher plant chloroplast GAPDH indeed derives from the genome of a cyanobacterium-like endosymbiont. But two additional GAPDH genes were found in the Anabaena genome and, surprisingly, one of these sequences is very similar to nuclear genes encoding the GAPDH enzyme of glycolysis in plants, animals, and fungi. Evidence that the eukaryotic nuclear genes for glycolytic GAPDH, as well as the Calvin-cycle genes, are of eubacterial origin suggests that eukaryotic genomes are more highly chimeric than previously assumed.

Page Thumbnails

  • Thumbnail: Page 
8692
    8692
  • Thumbnail: Page 
8693
    8693
  • Thumbnail: Page 
8694
    8694
  • Thumbnail: Page 
8695
    8695
  • Thumbnail: Page 
8696
    8696