You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
NADPH:Ferredoxin Oxidoreductase Acts as a Paraquat Diaphoras and is a Member of the soxRS Regulon
Stefan I. Liochev, Alfred Hausladen, Wayne F. Beyer, Jr. and Irwin Fridovich
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 4 (Feb. 15, 1994), pp. 1328-1331
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2364093
Page Count: 4
You can always find the topics here!Topics: Ferredoxins, Regulon, Cytochromes, Enzymes, Proteins, Electrons, Gels, Oxidation, Amino acids, Biochemistry
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Soluble extracts of Escherichia coli contain four NADPH:paraquat diaphorases that were separable by anion-exchange HPLC over Mono Q. One of these was induced when the cells were exposed to paraquat. This was the case in a soxRS-competent strain but not in a soxRS-null strain, while a soxRS-constitutive strain overexpressed this diaphorase without the stimulus of exposure to paraquat. This NADPH: paraquat diaphorase could use cytochrome c or nitroblue tetrazolium as an electron acceptor, whereas O2 was a relatively poor acceptor. This diaphorase was identified as the NADPH: ferredoxin reductase. A role for reduced ferredoxin and flavodoxin in the adaptive soxRS response to oxidative stress and in the regulation of the redox status of SoxR is discussed.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences