You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Id-1 as a Possible Transcriptional Mediator of Muscle Disuse Atrophy
Kristian Gundersen and John P. Merlie
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 9 (Apr. 26, 1994), pp. 3647-3651
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2364507
Page Count: 5
You can always find the topics here!Topics: Transgenes, Transgenic animals, Muscular atrophy, Muscles, Messenger RNA, Muscle fibers, Denervation, Mice, RNA, Neurons
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Disuse of muscle leads to atrophy of the fibers. This atrophy is correlated with reduced transcription. We found that when muscle was denervated or paralyzed with a nerve impulse block, the mRNA for Id-1, a negative regulator of transcription, was increased 2- to 7-fold. To test the effect of high Id-1 levels in active muscles, we made transgenic mice in which Id-1 was overexpressed under control of regulatory elements which confer tissue- and fiber-type-specific expression in differentiated muscle cells. Fiber types with high transgene expression were atrophic compared to those in wild-type litter mates. In contrast, fiber types with low transgene expression displayed hypertrophy, presumably caused by an overload due to reduced strength in atrophic synergistic fibers. Apart from the selective effects on fiber caliber, the muscle tissue showed no signs of pathology, and apart from a characteristic slightly lower body weight, the transgenic animals looked and behaved normally. We suggest that in the mature muscle, Id-1 may be involved in regulating muscle fiber size at the transcriptional level during disuse.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences