You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Parasite Virulence and Disease Patterns in Plasmodium falciparum Malaria
Sunetra Gupta, Adrian V. S. Hill, Dominic Kwiatkowski, Alice M. Greenwood, Brian M. Greenwood and Karen P. Day
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 9 (Apr. 26, 1994), pp. 3715-3719
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2364521
Page Count: 5
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Heterogeneity in parasite virulence is one of several factors that have been proposed to contribute to the wide spectrum of disease severity in Plasmodium falciparum malaria. We use observed age-structured patterns of disease to define a population structure of P. falciparum, where the latter contains several independently transmitted antigenic types or "strains" that each induce some degree of strain-specific antidisease immunity upon infection. Patterns of incidence of severe and mild disease may be explained by assuming that a majority of these strains are associated with mild disease and that although severe malarial anemia is a complication occurring in a certain proportion of early infections with "mild" parasites, cerebral malaria is caused by a few distinct highly virulent strains. Considerable variation in parasite virulence, as a major factor of disease severity in malaria, is made possible by the absence of competition between the various parasite strains, arising from weak shared immune responses. The theoretical framework presented in this paper can explain other epidemiological observations, such as the results of interventions with insecticide-impregnated bednets.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences