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D-MEF2: A MADS Box Transcription Factor Expressed in Differentiating Mesoderm and Muscle Cell Lineages during Drosophila Embryogenesis
Brenda Lilly, Samuel Galewsky, Anthony B. Firulli, Robert A. Schulz and Eric N. Olson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 12 (Jun. 7, 1994), pp. 5662-5666
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2364800
Page Count: 5
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The myocyte enhancer factor (MEF) 2 family of transcription factors has been implicated in the regulation of muscle transcription in vertebrates. We have cloned a protein from Drosophila, termed D-MEF2, that shares extensive amino acid homology with the MADS (MCM1, Agamous, Deficiens, and serum-response factor) domains of the vertebrate MEF2 proteins. D-mef2 gene expression is first detected during Drosophila embryogenesis within mesodermal precursor cells prior to specification of the somatic and visceral muscle lineages. Expression of D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart development. D-mef2 expression precedes that of the MyoD homologue, nautilus, and, in contrast to nautilus, D-mef2 appears to be expressed in all somatic and visceral muscle cell precursors. Its temporal and spatial expression patterns suggest that D-mef2 may play an important role in commitment of mesoderm to myogenic lineages.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences