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The Calcitonin Gene is Expressed in Salmon Gills
Kelly Martial, Laurence Maubras, Jacqueline Taboulet, Annick Jullienne, Michael Berry, Gerard Milhaud, A. A. Benson, M. S. Moukhatar and Michele Cressent
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 11 (May 24, 1994), pp. 4912-4914
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2364880
Page Count: 3
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Calcitonin is an important physiological regulator of salmon gills. Although the calcitonin receptor was found in salmon gills, the critical question concerning the source of the hormone remained unanswered. In this communication, evidence is presented for expression of calcitonin mRNA and its encoded peptide in gills of the pink salmon, Oncorhynchus gorbuscha. The expression of calcitonin gene transcripts was demonstrated by reverse transcription-polymerase chain reaction, Southern hybridization, and sequencing. The sequencing identified a sequence corresponding to that of exon 4 of the salmon calcitonin gene. Expression of the encoded calcitonin gene in gills was detected by radioimmunoassay in gill extracts. This synthesis of calcitonin in gills, which also possess specific receptors to the peptide, suggests function of an autocrine or paracrine process producing calcitonin in this tissue. These observations confirm and extend previous reports on the physiological role of calcitonin in fish gills.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences