Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support

Oxidative Damage and Mitochondrial Decay in Aging

Mark K. Shigenaga, Tory M. Hagen and Bruce N. Ames
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 23 (Nov. 8, 1994), pp. 10771-10778
Stable URL: http://www.jstor.org/stable/2365473
Page Count: 8
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
If you need an accessible version of this item please contact JSTOR User Support
Oxidative Damage and Mitochondrial Decay in Aging
Preview not available

Abstract

We argue for the critical role of oxidative damage in causing the mitochondrial dysfunction of aging. Oxidants generated by mitochondria appear to be the major source of the oxidative lesions that accumulate with age. Several mitochondrial functions deecline with age. The contributing factors include the intrinsic rate of proton leakage across the inner mitochondrial membrane (a correlate of oxidant formation), decreased membrane fluidity, and decreased levels and function of cardiolipin, which supports the function of many of the proteins of the inner mitochondrial membrance. Acetyl-L-carnitine, a high-energy mitochondrial substrate, appears to reverse many age-associated deficits in cellular function, in part by increasing cellular ATP production. Such evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging.

Page Thumbnails

  • Thumbnail: Page 
10771
    10771
  • Thumbnail: Page 
10772
    10772
  • Thumbnail: Page 
10773
    10773
  • Thumbnail: Page 
10774
    10774
  • Thumbnail: Page 
10775
    10775
  • Thumbnail: Page 
10776
    10776
  • Thumbnail: Page 
10777
    10777
  • Thumbnail: Page 
10778
    10778